Glucocorticoids on Nasal Polyps ?

 Recent study shows that fibroblasts from patients with Nasal Polyps and asthma who have a poor clinical response to Treatment with glucocorticoids, display a relative resistance tothe anti-proliferative effects of treatment with glucocorticoids, compared to fibroblasts from control nasal mucosa.

 In addition, glucocorticoids failed to inhibit collagen expression in any fibroblast type. In contrast, glucocorticoids seffectively down-regulated IL-6 and IL-8 production by nasal fibroblasts, though nasal polyps fibroblasts were less sensitive to dexamethasone than fibroblasts. 

Overall, this findings reinforce the concept that glucocorticoids are less effective inreducing fibrosis and remodelling of the airways than inreducing inflammation. This results also suggest that the impaired sensitivity of nasal polyp fibroblasts to the invitroanti-proliferative and anti-inflammatory effects of glucocorticoids concurs in part with the poor clinical response that these nasal polyp patients show to glucocorticoid treatment.

Read more : How to Cure Nasal Polyps Permanently and Naturally at Home ?