Is Nasal Polyps Genetic ? How to Get Rid Of Nasal Polyps at Home ?

 

Most genetic studies of Nasal Polyps have focused on the role of innate immunity in the pathophysiology of CRS. Most of these studies are candidate gene studies, which compare the allele frequencies of Single Nucleotide Polymorphisms (SNPs) within genes that are suspected a priori of being involved with the disease among patients with CRS and controls. However, association studies usually have inadequate power, mostly due to highly heterogeneous study groups, and limited ability to generate novel information, once can-didate genes are selected based on what is suspected about the disease. Conversely, Genome-Wide Association Studies (GWAS) use a hypothesis-independent approach to exam¬ine a number of polymorphisms across the entire human genome. However, GWAS of CRS are still lacking due to the high costs and large patient cohorts required. DNA pool-based GWAS (pGWAS) that replace individual DNA geno- typing by pooled genomic DNA are an alternative to reduce costs.

Genetic studies of Nasal Polyps are promising and may offer insights into the pathophysiology of the disease, which is likely affected by multiple genetic factors. Nevertheless, there are several barriers to understanding the pathophy-siology of Nasal Polyps including the variability in phenotyping, lack of cohort studies, limited research funding, and lack of a clear understanding of how genetic and epigenetic changes may trigger the disease.

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