Is There Any Way to Treat Nasal Polyps ?

Nasal polyposis is a chronic inflammatory disease ofthe nasal mucosa with inflammatory cells, infiltration,especially eosinophil, and structural modifications ofthe epithelium (secretory hyperplasia and squamousmetaplasia) and lamina propria ( basement meme-brane thickening, extracellular matrix accumulationand fibrosis). Although the pathophysiology of nasal polyps is not clearly known, new  hypothesis on the formation of nasal polyps is classified nasal polyps as softtissue masses of edematous (60%), glandular-cystic(27%) and fibrous (13%) types, which exhibit intactepithelium on the surface with massive edema fluid,and pseudocyst formation in the deeper layers. 

Polyp tissue seems to be significantly denervated, and it is postulated that the open endothelial junctions of venules might be responsible for the vascular leakage. However, the pathophysiological mechanisms of the formation and growth of nasal polyps remain poorly understood.

Remodeling in nasal polyps is discussed. Nasal polyps show a diversity of histogical findings. Although squamous metaplasia and goblet cells hypertrophy is observedin many patients, epithelial shedding, which is characteristic of asthma, is not observed in nasal polyps. The most striking finding of glands in nasal polyps is long shape. Histochemical analysis reveals deposition of types I, III, and V collagens in nasal polyps. Myofibroblasts, which are abundant in nasal polyps but rare in nasal mucosa, could be involved in the growth process of nasal polyps by inducing extracellular matrix accumulation. Although accumulation of extracellular matrix is a main feature of nasal polyps, its pathogenesis is not clearly known.

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